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You have been invited to trial Prism Cloud prior to its official launch during a limited, pre-release Beta period. GraphPad shall have no liability under the Prism Cloud Terms of Use, up to and including any indemnification obligations, arising out of, or related to any use of Prism Cloud during the Beta trial period by you, your authorized users and your group network of collaborators and any other users accessing the Prism Cloud service through you or your group. Any use of the Beta release of Prism Cloud will be solely at your own risk and may be subject to additional requirements as specified by GraphPad. Prism Cloud is still in development and GraphPad may change aspects of the Prism Cloud at any time, including prior to general release. GraphPad is not obligated to provide support for Prism Cloud during the Beta period and GraphPad may, at its sole discretion, cease providing Prism Cloud as a web-based service available for use with the Service during the Beta period. GraphPad reserves the right to invite and exclude select customers to participate in the free trial of the Beta release of Prism Cloud subject to certain operational considerations and feature capabilities.
how to reset trial period for graphpad prism
Men is generally a curious creature, so he/she wonders how the applications knows, when the trial time started, wether the time trial is over and wether it is possible do some trick (I mean simple trick, not reverse engineering) and reset the trial period.
You might think to yourself, how does the shareware knows how many days left in the trial period? Most of the time these commercial and freeware protectors drop some information somewhere deep inside your computer after installation so they know when it was installed and then comparing with the official current time pulled from the Internet. It is possible to find the location that records that information by using file or registry monitoring software including third party uninstaller software such as Revo Uninstaller but it can be tedious and frustrating work.
Do note that Trial-Reset does not modify the shareware in anyway. It simply cleans the registry keys generated by the protectors which are normally not removed even after uninstalling the software. This is how a lot of shareware knows you have no trial period left, even if you uninstall and re-install the program again. Trial-Reset is very easy to use. To start scanning, simply click on the All located at the bottom left. The scanning will take a while since some of the methods require scanning the hard drive. The right pane will show all the detected keys that are used by any shareware titles.
You can backup, view or delete the keys, add to protect or auto cleaning list from the right click context menu. If you have a lot of shareware installed, there will be quite a number of results and you will need to do a trial and error to find the key that is associated with the software that you want to reset the trial period.
Trial software is basically a program you download and use for a certain period of time. The software may include full or limited features. Whenever you install trial software, entries are downloaded into the registry much like other applications. To remove the entries and clean the registry, you have to first uninstall the trial application. Cleaning and removing trial software registry entries after uninstalling helps minimize the possibility of future registry problems.
Trial software allows the user to evaluate the software for a limited amount of time. After that trial period (usually 15 to 90 days) the user can decide whether to buy the software or not. Even though, most trial software products are only time-limited some also have feature limitations.
IBM is providing extended trial versions of SPSS Statistics to all users to assist them through the COVID-19 period. At the moment, these are end-dated 1st of June 2020. This date is subject to change and this page will be updated if any changes occur. Installation Guide (Mac) Installation Guide (Windows)
Our results could be viewed as in contradiction with the findings of the ANDROMEDA-SHOCK trial [14], particularly in the fluid boluses administered during the intervention period. However, the design of the studies was markedly different. First, the time-period for recruitment was maximum 4 h, since septic shock diagnosis in ANDROMEDA-SHOCK and up to 24 h in the present study. Fluid boluses administered in CRT-T were almost a half of those in LAC-T, and although this difference is not significant, it may suggest that the benefits of CRT-guided resuscitation may extend for longer periods than the limits imposed by ANDROMEDA-SHOCK. Second, in the present study only fluid-responsive patients were included, and in addition it included fluid administration as the single intervention. Despite these differences in design, LAC-T, the challenged gold-standard, was not superior in any of the studied variables, and patients in CRT-T achieved their goal in a higher proportion of cases during the intervention period.
Layout table for study information Study Type : Interventional (Clinical Trial) ActualEnrollment : 422 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Investigating the Efficacy and Safety of Multiple Dupilumab Dose Regimens Administered as Monotherapy for Maintaining Treatment Response in Patients With Atopic Dermatitis Actual Study Start Date : March 25, 2015 Actual Primary Completion Date : July 2016 Actual Study Completion Date : October 18, 2016 Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Atopic dermatitis MedlinePlus related topics: Eczema Drug Information available for: Dupilumab U.S. FDA Resources Arms and Interventions Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Arm Intervention/treatment Placebo Comparator: PlaceboSubcutaneous injection of Placebo (for Dupilumab) was administered once weekly (QW) from Week 1 (Day 1) to Week 36. Drug: PlaceboSubcutaneous injection of Placebo (for Dupilumab) was administered once weekly (QW). Experimental: Dupilumab 300 mg Q8WSubcutaneous injection of Dupilumab 300 milligram (mg) alternatively with placebo (matched to Dupilumab) was administered once every eight week (Q8W) from Week 1 to Week 36. Drug: DupilumabSubcutaneous injection of Dupilumab 300 mg alternatively with placebo (matched to Dupilumab) was administered.Other Names:REGN668
SAR231893
Experimental: Dupilumab 300 mg Q4WSubcutaneous injection of Dupilumab 300 mg alternatively with placebo (matched to Dupilumab) was administered once every four week (Q4W) from Week 1 to Week 36. Drug: DupilumabSubcutaneous injection of Dupilumab 300 mg alternatively with placebo (matched to Dupilumab) was administered.Other Names:REGN668
SAR231893
Experimental: Dupilumab 300 mg Q2W/QWSubcutaneous injection of Dupilumab 300 mg alternatively with placebo (matched to Dupilumab) was administered once every week (QW) or twice a week (Q2W) from Week 1 to Week 36. Drug: DupilumabSubcutaneous injection of Dupilumab 300 mg alternatively with placebo (matched to Dupilumab) was administered.Other Names:REGN668
SAR231893
Outcome Measures Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Primary Outcome Measures : Difference Between Current Study Baseline and Week 36 in Percent Change in EASI From Parent Study Baseline (NCT02277743 and NCT02277769) [ Time Frame: Baseline (Parent Study), Baseline (Current Study) and Week 36 (Current study) ]The EASI score was used to measure the severity and extent of AD and measured erythema, infiltration, excoriation and lichenification on 4 anatomic regions of the body: head, trunk, upper and lower extremities. The total EASI score ranges from 0 (minimum) to 72 (maximum) points, with the higher scores reflecting the worse severity of AD. Difference of percent change in EASI between current study baseline and week 36 in from parent study baseline (NCT02277743 and NCT02277769) was reported. Values after first rescue treatment used were set to missing before multiple imputation (MI). Percentage of Participants With Eczema Area and Severity Index >= 75% [EASI-75] at Baseline of Current Study Maintaining EASI-75 at Week 36 [ Time Frame: Week 36 ]The EASI score was used to measure the severity and extent of AD and measured erythema, infiltration, excoriation and lichenification on 4 anatomic regions of the body: head, trunk, upper and lower extremities. The total EASI score ranges from 0 (minimum) to 72 (maximum) points, with the higher scores reflecting the worse severity of AD. EASI-75 responders were the participants who achieved >=75% overall improvement in EASI score at Week 36. Values after first rescue treatment used were set to missing. Patients with missing value at week 36 were considered as a non-responder. Secondary Outcome Measures : Percentage of Participants Maintaining Investigator Global Assessment (IGA) Response Within 1 Point of Baseline at Week 36 [ Time Frame: Baseline, Week 36 ]IGA is an assessment scale used to determine severity of AD and clinical response to treatment on a 5-point scale (0 = clear; 1 = almost clear; 2 = mild; 3 = moderate; 4 = severe) based on erythema and papulation/infiltration. Therapeutic response is an IGA score of 0 (clear) or 1 (almost clear). Participants with IGA score of 0 or 1 at baseline and maintaining within 1 point of baseline were reported as responders. Values after first rescue treatment used were set to missing. Participants with missing value at a visit were considered as a non-responder. Percentage of Participants Maintaining Investigator Global Assessment (IGA) Response at 0 or 1 Point at Week 36 [ Time Frame: Week 36 ]IGA is an assessment scale used to determine severity of AD and clinical response to treatment on a 5-point scale (0 = clear; 1 = almost clear; 2 = mild; 3 = moderate; 4 = severe) based on erythema and papulation/infiltration. Therapeutic response is an IGA score of 0 (clear) or 1 (almost clear). Participants with IGA score of 0 or 1 at week 36 were reported as responders. Values after first rescue treatment were set to missing and participants with missing IGA scores at Week 36 were considered as non-responders. Percentage of Participants With Weekly Average of Peak Daily Pruritus Numerical Rating Scale (NRS) Score Increased by 3 or More Points From Baseline to Week 35 [ Time Frame: Baseline up to Week 35 ]Pruritus NRS was an assessment tool that was used to report the intensity of a participant's pruritus (itch), both maximum and average intensity, during a 24-hour recall period. Participants were asked the following question: how would a participant rate his itch at the worst moment during the previous 24 hours (for maximum itch intensity on a scale of 0 - 10 [0 = no itch; 10 = worst itch imaginable]). Values after first rescue treatment were set to missing and participants with missing peak NRS at Week 35 were considered as non-responders. Time to First Event of Investigator's Global Assessment (IGA) >= 2 for Participants With IGA 0 or 1 at Baseline [ Time Frame: Baseline up to Week 36 ]IGA is an assessment scale used to determine severity of AD and clinical response to treatment on a 5-point scale (0 = clear; 1 = almost clear; 2 = mild; 3 = moderate; 4 = severe) based on erythema and papulation/infiltration. Therapeutic response is an IGA score of 0 (clear) or 1 (almost clear). Percentage of Participants With Increased Investigator's Global Assessment (IGA) Score 3 or 4 at Week 36 [ Time Frame: Week 36 ]IGA is an assessment scale used to determine severity of AD and clinical response to treatment on a 5-point scale (0 = clear; 1 = almost clear; 2 = mild; 3 = moderate; 4 = severe) based on erythema and papulation/infiltration. Therapeutic response is an IGA score of 0 (clear) or 1 (almost clear). Values after first rescue treatment were set to missing and participants with missing IGA scores at Week 36 were considered as responders (i.e. having a increase 3 or 4 of IGA value). Percentage of Participants With Eczema Area and Severity Index-50 (EASI-50) (>= 50% Reduction in EASI Score) at Week 36 [ Time Frame: Week 36 ]The EASI score was used to measure the severity and extent of AD and measured erythema, infiltration, excoriation and lichenification on 4 anatomic regions of the body: head, trunk, upper and lower extremities. The total EASI score ranges from 0 (minimum) to 72 (maximum) points, with the higher scores reflecting the worse severity of AD. EASI-50 responders were the participants who achieved >= 50% overall improvement in EASI score from baseline to Week 36. Values after first rescue treatment were set to missing and participants with missing EASI-50 scores at Week 36 were considered as non-responders. Absolute Change From Baseline in Eczema Area and Severity Index (EASI) at Week 36 [ Time Frame: Baseline, Week 36 ]The EASI score was used to measure the severity and extent of AD and measured erythema, infiltration, excoriation and lichenification on 4 anatomic regions of the body: head, trunk, upper and lower extremities. The total EASI score ranges from 0 (minimum) to 72 (maximum) points, with the higher scores reflecting the worse severity of AD. Values after first rescue treatment were set to missing and participants with missing Values at Week 36 were imputed by using multiple imputation method. Absolute Change From Baseline in SCORing Atopic Dermatitis (SCORAD) Score at Week 36 [ Time Frame: Baseline, Week 36 ]SCORAD is a clinical tool for assessing the severity of AD developed by the European Task Force on Atopic Dermatitis (Severity scoring of atopic dermatitis: the SCORAD index). Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology (Basel) 186 (1): 23-31. 1993. Extent and intensity of eczema as well as subjective signs (insomnia, etc.) are assessed and scored. Total score ranges from 0 (absent disease) to 103 (severe disease). Values after first rescue treatment used were set to missing (censoring) before MI. Absolute Change From Baseline in Peak Daily Pruritus Numerical Rating Scale (NRS) Score at Week 35 [ Time Frame: Baseline, Week 35 ]Pruritus NRS was an assessment tool that was used to report the intensity of a participant's pruritus (itch), both maximum and average intensity, during a 24-hour recall period. Participants were asked the following question: how would a participant rate his itch at the worst moment during the previous 24 hours (for maximum itch intensity on a scale of 0 - 10 [0 = no itch; 10 = worst itch imaginable]). Values after first rescue treatment used were set to missing before MI. Absolute Change From Baseline in Body Surface Area (BSA) Through Week 36 [ Time Frame: Baseline through Week 36 ]BSA affected by AD was assessed for each section of the body (the possible highest score for each region was: head and neck [9%], anterior trunk [18%], back [18%], upper limbs [18%], lower limbs [36%], and genitals [1%]). It was reported as a percentage of all major body sections combined. Values after first rescue treatment used were set to missing (censoring) before MI. Absolute Change From Baseline Through in Patient Oriented Eczema Measure (POEM) Through Week 36 [ Time Frame: Baseline through Week 36 ]The POEM is a 7-item questionnaire that assesses disease symptoms (dryness, itching, flaking, cracking, sleep loss, bleeding and weeping) with a scoring system of 0 (absent disease) to 28 (severe disease) (high score indicative of poor quality of life [QOL]). Values after first rescue treatment used were set to missing (censoring) before MI. Absolute Change From Baseline in Dermatology Life Quality Index (DLQI) Through Week 36 [ Time Frame: Baseline through Week 36 ]The DLQI is a 10-item, validated questionnaire used in clinical practice and clinical trials to assess the impact of AD disease symptoms and treatment on quality of life (QOL). The 10 questions assessed QOL over the past week, with an overall scoring of 0 (absent disease) to 30 (severe disease); a high score was indicative of a poor QOL. Values after first rescue treatment used were set to missing before MI. Absolute Change From Baseline in Hospital Anxiety Depression Scale (HADS) Through Week 36 [ Time Frame: Baseline through Week 36 ]HADS is a fourteen item scale. Seven of the items relate to anxiety and seven items relate to depression. Each item on the questionnaire is scored from 0 (minimum score) - 3 (maximum score) and this means that a person can score between 0 (no symptoms) and 21 (severe symptoms) for either anxiety or depression. Cut-offs for identifying psychiatric distress has been reported as 7 to 8 for possible presence, 10 to 11 for probable presence, and 14 to 15 for severe anxiety or depression. Values after first rescue treatment used were set to missing before MI. Difference Between Current Study Baseline and Week 36 in Percent Change in SCORAD From Parent Study Baseline [ Time Frame: Baseline (Parent Study), Baseline (Current Study) and Week 36 (Current study) ]SCORAD is a clinical tool for assessing the severity of AD developed by the European Task Force on Atopic Dermatitis (Severity scoring of atopic dermatitis: the SCORAD index). Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology (Basel) 186 (1): 23-31. 1993. Extent and intensity of eczema as well as subjective signs (insomnia, etc.) are assessed and scored. Total score ranges from 0 (absent disease) to 103 (severe disease). Values after first rescue treatment used were set to missing before MI. Difference Between Current Study Baseline and Week 35 in Percent Change in Peak Weekly Pruritus NRS From Parent Study Baseline [ Time Frame: Baseline (Parent Study), Baseline (Current Study) and Week 35 (Current study) ]Pruritus NRS was an assessment tool that was used to report the intensity of a participant's pruritus (itch), both maximum and average intensity, during a 24-hour recall period. Participants were asked the following question: how would a participant rate his itch at the worst moment during the previous 24 hours (for maximum itch intensity on a scale of 0 - 10 [0 = no itch; 10 = worst itch imaginable]). Values after first rescue treatment used were set to missing before MI. Annualized Event Rate of Skin Infection Treatment- Emergent Adverse Events (TEAEs) [ Time Frame: Baseline through Week 36 ]Any untoward medical occurrence in a participant who received investigational medicinal product (IMP) was considered an AE without regard to possibility of causal relationship with this treatment. Treatment- emergent adverse events (TEAEs) were defined as AEs that developed or worsened or became serious during on- treatment period (time from the first dose of study drug up to the end of study [Week 36]). A serious adverse event (SAE) was defined as any untoward medical occurrence that resulted in any of the following outcomes: death, life- threatening, required initial or prolonged in-patient hospitalization, persistent or significant disability/incapacity, congenital anomaly/birth defect, or considered as medically important event. Any TEAE included participants with both serious and non-serious AEs. Annualized Event Rate of Flares [ Time Frame: Baseline through week 36 ]Rate of Flares defined as worsening of disease requiring initiation or escalation of rescue treatment. Percentage of Well-Controlled Weeks During the On-treatment Period [ Time Frame: Baseline through Week 36 ]Well-controlled weeks are those in which participants during their weekly IVRS call completion has their eczema been well-controlled over the last week during which no rescue treatments were administered. Percentage of well-controlled weeks during the on-treatment period were reported. Eligibility CriteriaGo to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Key Inclusion Criteria: 2ff7e9595c
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